Immobilization of glyoxylic acid on Wang resin

We report herein the simple preparation of immobilized glyoxylic acid, where the acid function is either linked through an amide or an ester bond to Wang resin. These compounds represent interesting aldehyde inputs for the generation of new libraries of small molecules.

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Bibliographic Details
Published in:Tetrahedron letters 2000-06, Vol.41 (26), p.5147-5150
Main Authors: Schlienger, Nathalie, Bryce, Martin R, Hansen, Thomas K
Format: Article
Language:English
Subjects:
aldehydes
solid-phase synthesis
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Description
Summary:We report herein the simple preparation of immobilized glyoxylic acid, where the acid function is either linked through an amide or an ester bond to Wang resin. These compounds represent interesting aldehyde inputs for the generation of new libraries of small molecules.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)00799-1