Hetero-Diels–Alder synthesis of the spiroketal fragment of reveromycin A

The asymmetric synthesis of the 6,6-spiroketal fragment 15 of the epidermal growth factor inhibitor reveromycin A ( 1) is described. A hetero-Diels–Alder reaction was utilized to construct the 6,6-spiroketal 14 and subsequent stereoselective hydroboration provided reveromycin A spiroketal 15.

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Bibliographic Details
Published in:Tetrahedron letters 2000-10, Vol.41 (44), p.8591-8594
Main Authors: El Sous, Mariana, Rizzacasa, Mark A
Format: Article
Language:English
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Summary:The asymmetric synthesis of the 6,6-spiroketal fragment 15 of the epidermal growth factor inhibitor reveromycin A ( 1) is described. A hetero-Diels–Alder reaction was utilized to construct the 6,6-spiroketal 14 and subsequent stereoselective hydroboration provided reveromycin A spiroketal 15.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)01494-5