Macrolactonization of hydroxy acids using a polymer bound carbodiimide

An efficient macrolactonization procedure using a polymer bound carbodiimide is described. The procedure uses the polymer supported reagent as a replacement for dicyclohexylcarbodiimide and thus considerably simplifies the workup for such reactions. Partitioning between macrolactone and diolide is s...

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Bibliographic Details
Published in:Tetrahedron letters 2000-11, Vol.41 (45), p.8673-8676
Main Authors: Keck, Gary E, Sanchez, Carina, Wager, Carrie A
Format: Article
Language:English
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Summary:An efficient macrolactonization procedure using a polymer bound carbodiimide is described. The procedure uses the polymer supported reagent as a replacement for dicyclohexylcarbodiimide and thus considerably simplifies the workup for such reactions. Partitioning between macrolactone and diolide is shown to depend upon the equivalents of reagent used in cases for which lactonization is difficult.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)01569-0