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Efficient synthesis of 4,4-disubstituted-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxides

A simple method for the preparation of 4,4-disubstituted-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxides is described. Treatment of N-sulfonyl ketimines 2 and 3 with different carbon nucleophiles afforded the corresponding of 4,4-disubstituted-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxides 1...

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Bibliographic Details
Published in:Tetrahedron letters 2000-12, Vol.41 (50), p.9825-9828
Main Authors: Domı́nguez, Esteban, de Blas, Jesús, del Prado, Miriam, Aranda, M.Teresa, Carreño, M.Carmen, Garcı́a Ruano, José L.
Format: Article
Language:English
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Summary:A simple method for the preparation of 4,4-disubstituted-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxides is described. Treatment of N-sulfonyl ketimines 2 and 3 with different carbon nucleophiles afforded the corresponding of 4,4-disubstituted-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxides 1 in isolated yields of 35–84%.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)01779-2