Preparation of enantiopure 4-arylmandelic acids via a Pd/C catalysed Suzuki coupling of enantiopure 4-bromomandelic acid

A library of enantiomerically pure mandelic acid derivatives has been prepared using a palladium on carbon catalysed Suzuki reaction. The chirality was derived from enantiomerically pure 4-bromomandelic acid which was obtained by resolution with α-methylbenzylamine. A library of enantiomerically pur...

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Bibliographic Details
Published in:Tetrahedron letters 2001-02, Vol.42 (9), p.1765-1767
Main Authors: Dyer, Ulrich C, Shapland, Peter D, Tiffin, Peter D
Format: Article
Language:English
Subjects:
4-bromomandelic acid
biaryl compounds
palladium on carbon
Suzuki reaction
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Summary:A library of enantiomerically pure mandelic acid derivatives has been prepared using a palladium on carbon catalysed Suzuki reaction. The chirality was derived from enantiomerically pure 4-bromomandelic acid which was obtained by resolution with α-methylbenzylamine. A library of enantiomerically pure mandelic acid derivatives has been prepared using a palladium on carbon catalysed Suzuki reaction. The chirality was derived from enantiomerically pure 4-bromomandelic acid which was obtained by resolution with α-methylbenzylamine.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)02304-2