Transition-metal complex-catalyzed reduction of amides with hydrosilanes: a facile transformation of amides to amines

The reaction of amides with hydrosilanes is catalyzed by a variety of transition-metal complexes in the presence or absence of halides and amines as co-catalysts to afford the corresponding amines in good yields. Reduction of amides with hydrosilanes takes place in the prescence of transition-metal...

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Bibliographic Details
Published in:Tetrahedron letters 2001-03, Vol.42 (10), p.1945-1947
Main Authors: Igarashi, Mamoru, Fuchikami, Takamasa
Format: Article
Language:English
Subjects:
amides
amines
catalysts
reduction
silicon and compounds
transition metals
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Summary:The reaction of amides with hydrosilanes is catalyzed by a variety of transition-metal complexes in the presence or absence of halides and amines as co-catalysts to afford the corresponding amines in good yields. Reduction of amides with hydrosilanes takes place in the prescence of transition-metal catalysts to afford the corresponding amines in moderate to good yields.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(01)00039-9