The conversion of alcohols to halides using a filterable phosphine source

The conversion of primary and secondary alcohols to chlorides and bromides using 1,2-bis(diphenylphosphino)ethane (diphos) is described. Use of this reagent in lieu of the typical triphenylphosphine–carbontetrahalide complex provides a facile means of purifying the desired halide from the phosphine–...

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Bibliographic Details
Published in:Tetrahedron letters 2001-03, Vol.42 (13), p.2459-2460
Main Authors: Pollastri, Michael P, Sagal, John F, Chang, George
Format: Article
Language:English
Subjects:
alcohol
diphos
phosphine oxides
phosphines
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Summary:The conversion of primary and secondary alcohols to chlorides and bromides using 1,2-bis(diphenylphosphino)ethane (diphos) is described. Use of this reagent in lieu of the typical triphenylphosphine–carbontetrahalide complex provides a facile means of purifying the desired halide from the phosphine–oxide byproduct. The conversion of primary and secondary alcohols to chlorides and bromides using 1,2-bis(diphenylphosphino)ethane (diphos) is described. Use of this reagent in lieu of the typical triphenylphosphine–carbontetrahalide complex provides a facile means of purifying the desired halide from the phosphine–oxide byproduct.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(01)00220-9