Kahakamides A and B, new neosidomycin metabolites from a marine-derived actinomycete

Two new indole nucleosides kahakamides A ( 1 ) and B ( 2 ) were isolated from the actinomycete Nocardiopsis dassonvillei, obtained from a shallow water sediment sample collected on the island of Kauai, Hawaii. Compounds 1 and 2 are related to the neosidomycin antibiotics, a group of rare indole- N-g...

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Bibliographic Details
Published in:Tetrahedron letters 2001-07, Vol.42 (31), p.5133-5135
Main Authors: Schumacher, Robert W, Harrigan, Beth L, Davidson, Bradley S
Format: Article
Language:English
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Summary:Two new indole nucleosides kahakamides A ( 1 ) and B ( 2 ) were isolated from the actinomycete Nocardiopsis dassonvillei, obtained from a shallow water sediment sample collected on the island of Kauai, Hawaii. Compounds 1 and 2 are related to the neosidomycin antibiotics, a group of rare indole- N-glycosides, and their structures were determined using spectroscopic methods. Compound 1 exhibited antimicrobial activity toward the Gram positive bacterium Bacillus subtilis. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(01)00979-0