Orostanal, a novel abeo-sterol inducing apoptosis in leukemia cell from a marine sponge, Stelletta hiwasaensis

A sterol derivative, orostanal, was obtained from a marine sponge of Stelletta hiwasaensis. Spectroscopic analysis and synthetic study revealed its structure as a novel 5(6→7)abeo-sterol. Orostanal and its synthetic analog induce apoptosis in human acute promyelotic leukemia cell. Graphic

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Bibliographic Details
Published in:Tetrahedron letters 2001-09, Vol.42 (36), p.6349-6351
Main Authors: Miyamoto, Tomofumi, Kodama, Kota, Aramaki, Yuko, Higuchi, Ryuichi, Van Soest, Rob W.M
Format: Article
Language:English
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Summary:A sterol derivative, orostanal, was obtained from a marine sponge of Stelletta hiwasaensis. Spectroscopic analysis and synthetic study revealed its structure as a novel 5(6→7)abeo-sterol. Orostanal and its synthetic analog induce apoptosis in human acute promyelotic leukemia cell. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(01)01278-3