Solid-phase combinatorial synthesis of polyamine derivatives using aminoalcohol building blocks

A systematic study of nucleophilic displacement of mesyl groups using benzylamine was carried out on Multipin Synphase™ supports. The optimal conditions were applied for the combinatorial synthesis of polyamine derivatives from commercially available aminoalcohols and amines. Using the ‘split-mix’ t...

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Bibliographic Details
Published in:Tetrahedron letters 2001-09, Vol.42 (38), p.6655-6658
Main Authors: Renault, Jacques, Lebranchu, Marina, Lecat, Anne, Uriac, Philippe
Format: Article
Language:English
Subjects:
combinatorial synthesis
polyamines
solid-phase synthesis
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Summary:A systematic study of nucleophilic displacement of mesyl groups using benzylamine was carried out on Multipin Synphase™ supports. The optimal conditions were applied for the combinatorial synthesis of polyamine derivatives from commercially available aminoalcohols and amines. Using the ‘split-mix’ technique, a series of 16 individual polyamines was synthesised from commercially available aminoalcohols and amines.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(01)01352-1