Total synthesis of (±)-homopumiliotoxin 223G

The total synthesis of (±)-homopumiliotoxin 223G was achieved in six steps and 14% yield through the addition of 5-methyl-2-triisopropylsilyoxyfuran ( 3 ) to the N-acyliminium ion derived from N-Cbz 2-methoxypiperidine featuring bicyclic lactam 9b as the key intermediate. Graphic

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2001-10, Vol.42 (40), p.6999-7001
Main Authors: Santos, Leonardo Silva, Pilli, Ronaldo Aloise
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The total synthesis of (±)-homopumiliotoxin 223G was achieved in six steps and 14% yield through the addition of 5-methyl-2-triisopropylsilyoxyfuran ( 3 ) to the N-acyliminium ion derived from N-Cbz 2-methoxypiperidine featuring bicyclic lactam 9b as the key intermediate. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(01)01389-2