Chemoselective N-acylation of amino alcohols promoted by magnesium oxide in aqueous organic solution

The reaction of hydrophilic amino alcohols with acid chlorides in the presence of magnesium oxide in aqueous organic solution (THF/H 2O=4:1) cleanly provided alkanolamides. Graphic

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Bibliographic Details
Published in:Tetrahedron letters 2002-01, Vol.43 (2), p.277-279
Main Authors: Kim, Duck-Hee, Rho, Ho-Sik, You, Jae Won, Lee, Jong Chan
Format: Article
Language:English
Subjects:
acid chloride
amides
amine
aqueous solution
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Description
Summary:The reaction of hydrophilic amino alcohols with acid chlorides in the presence of magnesium oxide in aqueous organic solution (THF/H 2O=4:1) cleanly provided alkanolamides. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(01)02134-7