Synthesis of 14-fluorodoxorubicin

Synthesis of the novel anthracycline 14-fluorodoxorubicin is described. A key step in the synthesis is the hydrolysis of 14-bromo,14-fluoro derivative 14 with AgBF 4 and DMSO, to give the geminal fluorohydrin system. Graphic

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Bibliographic Details
Published in:Tetrahedron letters 2002-04, Vol.43 (15), p.2867-2871
Main Authors: Berettoni, M., Cipollone, A., Olivieri, L., Palomba, D., Arcamone, F., Maggi, C.A., Animati, F.
Format: Article
Language:English
Subjects:
anthracycline
doxorubicin
fluoroanthracycline
fluorohydrin
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Description
Summary:Synthesis of the novel anthracycline 14-fluorodoxorubicin is described. A key step in the synthesis is the hydrolysis of 14-bromo,14-fluoro derivative 14 with AgBF 4 and DMSO, to give the geminal fluorohydrin system. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(02)00299-X