Novel solid-phase synthesis of 2,6-disubstituted 4(3 H)-quinazolinones for combinatorial library generation

A novel procedure for the synthesis of 6-alkoxy-2-amino-4(3 H)-quinazolinones from 2,4-dichloro-6-hydroxyquinazoline, amines and alcohols using Wang resin is described. Graphic

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Bibliographic Details
Published in:Tetrahedron letters 2002-04, Vol.43 (16), p.2971-2974
Main Authors: Wéber, Csaba, Bielik, Attila, Szendrei, Györgyi I, Greiner, István
Format: Article
Language:English
Subjects:
4(3 H)-quinazolinones
Mitsunobu
solid phase
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Description
Summary:A novel procedure for the synthesis of 6-alkoxy-2-amino-4(3 H)-quinazolinones from 2,4-dichloro-6-hydroxyquinazoline, amines and alcohols using Wang resin is described. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(02)00419-7