Synthesis of benzyl (6 S)-1,3-dichloro-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2- a]pyrazine-6-carboxylic ester, a new conformationally constrained peptidomimetic derivative

We describe the synthesis of benzyl (6 S)-1,3-dichloro-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2- a]pyrazine-6-carboxylic ester, a new conformationally constrained peptidomimetic derivative. This compound is prepared in seven steps from ( S)-pyroglutamic acid as starting material. Graphic

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Bibliographic Details
Published in:Tetrahedron letters 2002-05, Vol.43 (19), p.3499-3501
Main Authors: Gloanec, Philippe, Hervé, Yolande, Brémand, Nathalie, Lecouvé, Jean-Pierre, Bréard, Fabienne, De Nanteuil, Guillaume
Format: Article
Language:English
Subjects:
4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2- a]pyrazine
peptidomimetic
pyroglutamic acid
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Summary:We describe the synthesis of benzyl (6 S)-1,3-dichloro-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2- a]pyrazine-6-carboxylic ester, a new conformationally constrained peptidomimetic derivative. This compound is prepared in seven steps from ( S)-pyroglutamic acid as starting material. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(02)00574-9