Nucleophilic trifluoromethylation of acyl chlorides using the trifluoromethyl iodide/TDAE reagent

Chemoselective bis-trifluoromethylation of acyl chlorides using the CF 3I/TDAE-derived nucleophilic trifluoromethyl anion reagent is reported. Very high yields are obtained of an ester product formed by sequential nucleophilic bis-trifluoromethylation, followed by acylation of the resultant alcohola...

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Bibliographic Details
Published in:Tetrahedron letters 2002-06, Vol.43 (24), p.4317-4319
Main Authors: Takechi, Naoto, Aı̈t-Mohand, Samia, Médebielle, Maurice, Dolbier, William R.
Format: Article
Language:English
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Summary:Chemoselective bis-trifluoromethylation of acyl chlorides using the CF 3I/TDAE-derived nucleophilic trifluoromethyl anion reagent is reported. Very high yields are obtained of an ester product formed by sequential nucleophilic bis-trifluoromethylation, followed by acylation of the resultant alcoholate. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(02)00800-6