Utility of 4,6-dichloro-2-(methylthio)-5-nitropyrimidine. An efficient solid-phase synthesis of olomoucine

4,6-Dichloro-2-(methylthio)-5-nitropyrimidine has been utilized as a building block for an efficient nine-step synthesis of olomoucine. The methodology reported herein is applicable to the regiocontrolled solution and solid-phase synthesis of libraries of highly substituted purines, as well as other...

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Bibliographic Details
Published in:Tetrahedron letters 2002-11, Vol.43 (45), p.8071-8073
Main Authors: Hammarström, Lars G.J, Smith, David B, Talamás, Francisco X, Labadie, Sharada S, Krauss, Nancy E
Format: Article
Language:English
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Summary:4,6-Dichloro-2-(methylthio)-5-nitropyrimidine has been utilized as a building block for an efficient nine-step synthesis of olomoucine. The methodology reported herein is applicable to the regiocontrolled solution and solid-phase synthesis of libraries of highly substituted purines, as well as other related scaffolds. 4,6-Dichloro-2-(methylthio)-5-nitropyrimidine has been utilized as the starting material for an efficient solid-phase synthesis of olomoucine. The methodology disclosed is applicable to the synthesis of libraries of fully substituted purines.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(02)01953-6