Synthesis and absolute configuration of three natural ent-halimanolides with biological activity

The first three natural ent-halimanolides known until now have been synthesized from ent-halimic acid. Their structure have been confirmed as well as their absolute configurations established. Bestmann methodology has been used for the synthesis of butenolides and for the γ-hydroxybutenolides synthe...

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Bibliographic Details
Published in:Tetrahedron letters 2003-01, Vol.44 (2), p.369-372
Main Authors: Marcos, I.S, Pedrero, A.B, Sexmero, M.J, Diez, D, Basabe, P, Hernández, F.A, Urones, J.G
Format: Article
Language:English
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Summary:The first three natural ent-halimanolides known until now have been synthesized from ent-halimic acid. Their structure have been confirmed as well as their absolute configurations established. Bestmann methodology has been used for the synthesis of butenolides and for the γ-hydroxybutenolides synthesis the Boukouvalas method has been employed. Biological testing has been carried out on these compounds. The first three natural ent-halimanolides known until now have been synthesized from ent-halimic acid. Biological testing have been carried out on these compounds.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(02)02535-2