A convenient strategy of dimerization by microwave heating and using 2,5-diketopiperazine as scaffold

A novel and convenient microwave-assisted dimerization of an active peptide compound using the DKPs as scaffold is described. The key reaction giving rise to the diketopiperazine scaffold is the intermolecular coupling. No epimerization was detected in the reactions used. Conventional and microwave...

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Bibliographic Details
Published in:Tetrahedron letters 2003-02, Vol.44 (6), p.1145-1148
Main Authors: Santagada, Vincenzo, Fiorino, Ferdinando, Perissutti, Elisa, Severino, Beatrice, Terracciano, Sara, Cirino, Giuseppe, Caliendo, Giuseppe
Format: Article
Language:English
Subjects:
dimerization
microwave irradiation in solution
synthesis of diketopiperazine
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Summary:A novel and convenient microwave-assisted dimerization of an active peptide compound using the DKPs as scaffold is described. The key reaction giving rise to the diketopiperazine scaffold is the intermolecular coupling. No epimerization was detected in the reactions used. Conventional and microwave heating of the reactions are compared. Synthesis by microwave irradiation gave the desired compounds in higher yields and in shorter reaction times than those obtained by conventional heating. A novel and convenient microwave-assisted dimerization of an active peptide compound using the DKPs as scaffold is described. Conventional and microwave heating of the reactions are compared. Synthesis by microwave irradiation gave the desired compound in higher yields and in shorter reaction times than those obtained by conventional heating.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(02)02836-8