Silica sulfuric acid: an efficient and reusable catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1 H)-ones

Silica sulfuric acid efficiently catalyzes the three-component Biginelli reaction between an aldehyde, a β-dicarbonyl compound and urea or thiourea in refluxing ethanol to afford the corresponding dihydropyrimidinones in high yields. The catalyst is reusable and can be applied several times without...

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Bibliographic Details
Published in:Tetrahedron letters 2003-03, Vol.44 (14), p.2889-2891
Main Authors: Salehi, Peyman, Dabiri, Minoo, Zolfigol, Mohammad Ali, Bodaghi Fard, Mohammad Ali
Format: Article
Language:English
Subjects:
Biginelli reaction
catalysis
dihydropyrimidinones
silica sulfuric acid
solid phase
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Summary:Silica sulfuric acid efficiently catalyzes the three-component Biginelli reaction between an aldehyde, a β-dicarbonyl compound and urea or thiourea in refluxing ethanol to afford the corresponding dihydropyrimidinones in high yields. The catalyst is reusable and can be applied several times without any decrease in the yield of the reactions. Silica sulfuric acid efficiently catalyzes a one-pot synthesis of dihydropyrimidinones in high yields.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(03)00436-2