Bipyridyl-based diphosphine as an efficient ligand in the rhodium-catalyzed asymmetric conjugate addition of arylboronic acids to α,β-unsaturated ketones

Reactions of α,β-unsaturated ketones with excess arylboronic acids in the presence of a rhodium catalyst generated in situ from Rh(acac)(C 2H 4) and ( S)-P-Phos in dioxane/water at 100°C gave high yields of the corresponding products in up to 99% ee. Graphic

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Bibliographic Details
Published in:Tetrahedron letters 2003-08, Vol.44 (34), p.6505-6508
Main Authors: Shi, Qian, Xu, Lijin, Li, Xingshu, Jia, Xian, Wang, Ruihu, Au-Yeung, Terry T.-L., Chan, Albert S.C., Hayashi, Tamio, Cao, Rong, Hong, Maochun
Format: Article
Language:English
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Summary:Reactions of α,β-unsaturated ketones with excess arylboronic acids in the presence of a rhodium catalyst generated in situ from Rh(acac)(C 2H 4) and ( S)-P-Phos in dioxane/water at 100°C gave high yields of the corresponding products in up to 99% ee. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(03)01592-2