Fasicularin, a novel tricyclic alkaloid from the ascidian Nephteis fasicularis with selective activity against a DNA repair-deficient organism

A novel tricyclic alkaloid, fasicularin ( 1), was isolated from the Micronesian ascidian Nephteis fasicularis. The structure of 1 was elucidated primarily by interpretation of spectral data. Fasicularin was found to be active in a DNA damaging assay. A novel tricyclic alkaloid, fasicularin, was isol...

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Bibliographic Details
Published in:Tetrahedron letters 1997, Vol.38 (3), p.363-364
Main Authors: Patil, Ashok D., Freyer, Alan J., Reichwein, Rex, Carte, Brad, Killmer, Lewis B., Faucette, Leo, Johnson, Randall K., Faulkner, D.John
Format: Article
Language:English
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Summary:A novel tricyclic alkaloid, fasicularin ( 1), was isolated from the Micronesian ascidian Nephteis fasicularis. The structure of 1 was elucidated primarily by interpretation of spectral data. Fasicularin was found to be active in a DNA damaging assay. A novel tricyclic alkaloid, fasicularin, was isolated from the Micronesian ascidian Naphteis fasicularis. The structure of fasicularin was elucidated primarily by interpretation of spectral data. Fasicularin was found to be active in DNA damaging assay.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(96)02304-0