Asymmetric synthesis of dideazafolate antitumor agents via amidomethylation of nonracemic oxazolidinone imidates. Synthesis of LY309887, a cytotoxic dideazafolate analog related to lometrexol

The asymmetric synthesis of LY309887, a cytotoxic dideazatetrahydrofolate analog related to lometrexol, has been accomplished via an application of diastereoselective amidomethylation of a chiral titanium (IV) acyloxazolidinone enolate. The asymmetric synthesis of LY309887, a cytotoxic dideaza-tetra...

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Bibliographic Details
Published in:Tetrahedron letters 1997-02, Vol.38 (5), p.735-738
Main Authors: Barnett, Charles J., Wilson, Thomas M., Evans, David A., Somers, Todd C.
Format: Article
Language:English
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Summary:The asymmetric synthesis of LY309887, a cytotoxic dideazatetrahydrofolate analog related to lometrexol, has been accomplished via an application of diastereoselective amidomethylation of a chiral titanium (IV) acyloxazolidinone enolate. The asymmetric synthesis of LY309887, a cytotoxic dideaza-tetrahydrofolate analog related to lometrexol, has been accomplished via diastereoselective amidomethylation of a chiral titanium(IV) acyloxazolidinone enolate.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(96)02418-5