New strategy for the synthesis of large peptides as applied to the C-terminal cysteine-rich 41 amino acid fragment of the mouse agouti protein

In this new convergent peptide synthetic approach the advantages of the Fmoc and Boc techniques are combined. Boc-protected peptide fragments prepared on 2-chlorotrityl resin by Fmoc-technique were coupled sequentially in solution. As an example, the C-terminal (91–131) part of the agouti protein co...

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Bibliographic Details
Published in:Tetrahedron letters 1997-05, Vol.38 (18), p.3293-3296
Main Authors: Bódi, József, Süli-Vargha, Helga, Ludányi, Krisztina, Vékey, Károly, Orosz, György
Format: Article
Language:English
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Summary:In this new convergent peptide synthetic approach the advantages of the Fmoc and Boc techniques are combined. Boc-protected peptide fragments prepared on 2-chlorotrityl resin by Fmoc-technique were coupled sequentially in solution. As an example, the C-terminal (91–131) part of the agouti protein comprising all the 5 disulfide bridges in the original molecule has been synthesized by this method. The Boc-peptide fragments were synthesized on 2-chlorotrityl resin by Fmoc technique, cleaved and condensed in solution.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(97)00589-3