The ortho-substituted N, N-diacetylaniline as a selective acetylating reagent

Selective acetylation of the less hindered amino group in the presence of the more hindered amino group with the use of 2-trifluoromethyl- N, N-diacetylaniline 2c is described. This acetylation with 2c yielded the corresponding less hindered monoacetamide exclusively, simply, conveniently, and in go...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 1997-05, Vol.38 (21), p.3751-3754
Main Authors: Murakami, Yasuoki, Kondo, Kazuhiro, Miki, Kazuki, Akiyama, Yoko, Watanabe, Toshiko, Yokoyama, Yuusaku
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Selective acetylation of the less hindered amino group in the presence of the more hindered amino group with the use of 2-trifluoromethyl- N, N-diacetylaniline 2c is described. This acetylation with 2c yielded the corresponding less hindered monoacetamide exclusively, simply, conveniently, and in good yields. Highly selective acetylation of the less hindered amino group in the presence of the more hindered amino group with the use of 2-trifluoromethyl- N, N-diacetylaniline 2c is described.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(97)00745-4