Absolute configuration of norzoanthamine, a promising candidate for an osteoporotic drug

The absolute configuration of norzoanthamine ( 1) was determined to be 2 R 4 S, 6 S, 9 S, 10 R, 12 S, 13 R, 18 S, 21 S, and 22 S based on 1H NMR spectral data of the MTPA esters of norzoamthamine derivatives. The possible biogenesis of zoanthamines is also proposed. The absolute configuration of nor...

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Bibliographic Details
Published in:Tetrahedron letters 1997-08, Vol.38 (32), p.5683-5686
Main Authors: Kuramoto, Makoto, Hayashi, Koji, Fujitani, Yasuyuki, Yamaguchi, Kohji, Tsuji, Tomoko, Yamada, Kaoru, Ijuin, Yasuharu, Uemura, Daisuke
Format: Article
Language:English
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Summary:The absolute configuration of norzoanthamine ( 1) was determined to be 2 R 4 S, 6 S, 9 S, 10 R, 12 S, 13 R, 18 S, 21 S, and 22 S based on 1H NMR spectral data of the MTPA esters of norzoamthamine derivatives. The possible biogenesis of zoanthamines is also proposed. The absolute configuration of norzoanthamine ( 1) was determined to be 2 R, 4 S, 6 S, 9 S, 10 R, 12 S, 13 R, 18 S, 21 S, and 22 S based on 1H NMR spectral data of the MTPA ester of norzoanthamine derivatives. The new biogenetic pathway of zoanthamines was proposed.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(97)01238-0