Orthogonally protected imidazolidine-2-carboxylic acid, a new proline surrogate suitable for SPPS

N-Boc-N′-Fmoc-imidazolidine-2-carboxylic acid, easily prepared from N-Boc-N′-Fmoc-ethylenediamine and glyoxylic acid, is a racemic proline surrogate which can be used in Solid Phase Peptide Synthesis. Graphic

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Bibliographic Details
Published in:Tetrahedron letters 1998-04, Vol.39 (17), p.2569-2570
Main Authors: René, Loïc, Yaouancq, Loïc, Badet, Bernard
Format: Article
Language:English
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Description
Summary:N-Boc-N′-Fmoc-imidazolidine-2-carboxylic acid, easily prepared from N-Boc-N′-Fmoc-ethylenediamine and glyoxylic acid, is a racemic proline surrogate which can be used in Solid Phase Peptide Synthesis. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(98)00262-7