Mukaiyama-type, eight-membered ring closure: Access to a tricyclic system related to taxanes

Addition of Me 2CuLi, with in situ trapping by TMSCl, to Hagemann's ester derivative 13, furnished silyl enol ether 14. Mukaiyama-type cyclization of the latter compound gave the tricyclic derivative 15, structurally related to the taxane core. Addition of Me 2CuLi, with in situ trapping with T...

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Bibliographic Details
Published in:Tetrahedron letters 1998-05, Vol.39 (20), p.3133-3136
Main Authors: Cavé, Christian, Valancogne, Ingrid, Casas, Ramon, d'Angelo, Jean
Format: Article
Language:English
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Summary:Addition of Me 2CuLi, with in situ trapping by TMSCl, to Hagemann's ester derivative 13, furnished silyl enol ether 14. Mukaiyama-type cyclization of the latter compound gave the tricyclic derivative 15, structurally related to the taxane core. Addition of Me 2CuLi, with in situ trapping with TMSCI to Hagemann's ester derivative 13, furnished silyl enol ether 14. Mukalyama-type cyclization of the latter compound gave the tricyclic derivative 15, structurally related to the taxane core.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(98)00461-4