Synthesis of hydroperoxide and perketal derivatives of polyunsaturated fatty acids as potential antimalarial agents

Hydroperoxide derivatives of β-oxa-substituted polyunsaturated fatty acids were prepared by 15-lipoxygenase catalysed oxidation and perketal derivatives of fatty acid hydroperoxides were synthesized. The perketals are more stable than their parent fatty acid hydroperoxides, but less active as antima...

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Bibliographic Details
Published in:Tetrahedron letters 1998-06, Vol.39 (24), p.4401-4404
Main Authors: Pitt, Michael J., Easton, Christopher J., Robertson, Thomas A., Kumaratilake, Lakshmi M., Ferrante, Antonio, Poulos, Alfred, Rathjen, Deborah A.
Format: Article
Language:English
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Summary:Hydroperoxide derivatives of β-oxa-substituted polyunsaturated fatty acids were prepared by 15-lipoxygenase catalysed oxidation and perketal derivatives of fatty acid hydroperoxides were synthesized. The perketals are more stable than their parent fatty acid hydroperoxides, but less active as antimalarial agents in the in vitro growth inhibition of Plasmodium falciparum. Perketal derivatives of fatty acid hydroperoxides are more stable than their parent hydroperoxides, but less active as antimalarial agents. [Display omitted]
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(98)00747-3