Chaetochalasin A: A new bioactive metabolite from Chaetomium brasiliense

Chaetochalasin A ( 1), a new bioactive fungal metabolite with a previously undescribed ring system, has been isolated from an EtOAc extract of Chaetomium brasiliense (NRRL 22999). The structure of 1 was determined by NMR experiments and single-crystal X-ray diffraction analysis. Chaetochalasin A ( 1...

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Bibliographic Details
Published in:Tetrahedron letters 1998-10, Vol.39 (42), p.7633-7636
Main Authors: Oh, Hyuncheol, Swenson, Dale C., Gloer, James B., Wicklow, Donald T., Dowd, Patrick F.
Format: Article
Language:English
Subjects:
biologically active compounds
Chaetomium
chemical structure
fungi
natural products
secondary metabolites
x-ray crystal structure
X-ray diffraction
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Summary:Chaetochalasin A ( 1), a new bioactive fungal metabolite with a previously undescribed ring system, has been isolated from an EtOAc extract of Chaetomium brasiliense (NRRL 22999). The structure of 1 was determined by NMR experiments and single-crystal X-ray diffraction analysis. Chaetochalasin A ( 1), a new fungal metabolite with a novel ring system, was isolated from Chaetomium brasiliense. The structure of 1 was determined by NMR experiments and single-crystal X-ray diffraction analysis.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(98)01692-X