Preparation of ( S)-2-quinolylalanine by asymmetric hydrogenation

The synthesis of ( S)-2-quinolylalanine through asymmetric hydrogenation with ( S,S)-Et-DuPHOS-Rh is described. The reaction has been extended to other 2-pyridylalanie derivatives. The synthesis of ( S)-2-quinoylalanine through asymmetric hydrogenation with ( S,S)-Et-DuPHOS-Rh is described. The reac...

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Bibliographic Details
Published in:Tetrahedron letters 1999-02, Vol.40 (6), p.1211-1214
Main Authors: Jones, Stephen W., Palmer, Christopher F., Paul, Jane M., Tiffin, Peter D.
Format: Article
Language:English
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Summary:The synthesis of ( S)-2-quinolylalanine through asymmetric hydrogenation with ( S,S)-Et-DuPHOS-Rh is described. The reaction has been extended to other 2-pyridylalanie derivatives. The synthesis of ( S)-2-quinoylalanine through asymmetric hydrogenation with ( S,S)-Et-DuPHOS-Rh is described. The reaction has been extended to other 2-pyridylalanine derivatives.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(98)02568-4