Spiroxins, DNA cleaving antitumor antibiotics from a marine-derived fungus

The spiroxins ( 1–5) were purified from the culture extract of a marine-derived fungus. Their unique bisnaphthospiroketal structures were established by NMR spectroscopy. In addition to cytotoxicity, these compounds showed antibiotic activity and were active in a mouse xenograft model against human...

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Bibliographic Details
Published in:Tetrahedron letters 1999-03, Vol.40 (13), p.2489-2492
Main Authors: McDonald, Leonard A., Abbanat, Darren R., Barbieri, Laurel R., Bernan, Valerie S., Discafani, Carolyn M., Greenstein, Michael, Janota, Katarzyna, Korshalla, Joseph D., Lassota, Piotr, Tischler, Mark, Carter, Guy T.
Format: Article
Language:English
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Summary:The spiroxins ( 1–5) were purified from the culture extract of a marine-derived fungus. Their unique bisnaphthospiroketal structures were established by NMR spectroscopy. In addition to cytotoxicity, these compounds showed antibiotic activity and were active in a mouse xenograft model against human ovarian carcinoma. The mechanism of action of these compounds was shown to be due, in part, to their effect on DNA. Unique bisnaphthospiroketal-containing spiroxins ( 1–5) from a marine-derived fungus show antimicrobial, cytotoxic and antitumor activities. Compounds appear to act in part by a DNA-damaging mechanism.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(99)00242-7