An intramolecular, Ni(0)-mediated approach to the nonracemic biaryl portion of vancomycin

Using a tether derived from tartaric acid to which is attached two halogenated phenylglycine residues, a Ni(0)-induced biaryl coupling can be effected with complete control of axial chirality. Use of a nonracemic tether to induce S-axial chirality.

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Bibliographic Details
Published in:Tetrahedron letters 1999-05, Vol.40 (19), p.3677-3680
Main Authors: Lipshutz, Bruce H., Müller, Peter, Leinweber, Dirk
Format: Article
Language:English
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Summary:Using a tether derived from tartaric acid to which is attached two halogenated phenylglycine residues, a Ni(0)-induced biaryl coupling can be effected with complete control of axial chirality. Use of a nonracemic tether to induce S-axial chirality.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(99)00557-2