Synthesis, crystal structure and anti-malarial activity of novel spiro-1,2,4,5-tetraoxacycloalkanes

(Cycloalkylidene)bishydroperoxides 3 react with 1,n-dihaloalkanes (n = 3–6) in the presence of CsOHH 2O in DMF affording the corresponding spiro-1,2,4,5-tetraoxacycloalkanes 4 in moderate yields. Compound 4ba exhibits significant antimalarial activity in vitro against P. falciparum. Graphic

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Bibliographic Details
Published in:Tetrahedron letters 1999-05, Vol.40 (21), p.4077-4080
Main Authors: Tsuchiya, Kaoru, Hamada, Yoshiaki, Masuyama, Araki, Nojima, Masatomo, McCullough, Kevin J, Kim, Hye-Sook, Shibata, Yasuharu, Wataya, Yusuke
Format: Article
Language:English
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Summary:(Cycloalkylidene)bishydroperoxides 3 react with 1,n-dihaloalkanes (n = 3–6) in the presence of CsOHH 2O in DMF affording the corresponding spiro-1,2,4,5-tetraoxacycloalkanes 4 in moderate yields. Compound 4ba exhibits significant antimalarial activity in vitro against P. falciparum. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(99)00653-X