Synthesis of isoquinolines and pyridines via palladium-catalysed iminoannulation of allenes

Various isoquinolines and pyridines were prepared from aryl- and vinyl halides by a method which involves insertion of an allene into the PdC bond and intramolecular nucleophilic attack of the imine. Various vinyl and aryl imines were converted into isoquinolines and pyridines with high regioselect...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 1999-05, Vol.40 (22), p.4255-4258
Main Authors: Diederen, Jeroen J.H., Sinkeldam, Rene W., Frühauf, Hans-W., Hiemstra, Henk, Vrieze, Kees
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Various isoquinolines and pyridines were prepared from aryl- and vinyl halides by a method which involves insertion of an allene into the PdC bond and intramolecular nucleophilic attack of the imine. Various vinyl and aryl imines were converted into isoquinolines and pyridines with high regioselectivity by a new palladium catalysed route based on allenes.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(99)00700-5