Potent HIV protease inhibitors containing a novel (2-phenylsulfanyl-1-hydroxyethyl)amide isostere

Based on the concept of bioisosterism, we report the design and synthesis of new protease inhibitors. These new compounds incorporate in their backbone the synthon 2-N-Acyl-2-Phenylsulfanyl-1-Hydroxyethyl (I) which confers on the resulting compounds both in vitro activity on MT 4 infected cells and...

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Bibliographic Details
Published in:Tetrahedron letters 1999-05, Vol.40 (22), p.4173-4176
Main Authors: Rocheblave, L., Priem, G., De Michelis, C., Kraus, J.L.
Format: Article
Language:English
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Summary:Based on the concept of bioisosterism, we report the design and synthesis of new protease inhibitors. These new compounds incorporate in their backbone the synthon 2-N-Acyl-2-Phenylsulfanyl-1-Hydroxyethyl (I) which confers on the resulting compounds both in vitro activity on MT 4 infected cells and HIV-1 protease inhibition properties. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(99)00707-8