Stereoselective syntheses of cytoxazone, a novel cytokine modulator, and its stereoisomers

Cytoxazone, a novel cytokine modulator, and its stereoisomers were stereoselectively synthesized via stereocontrolled introduction of an azide group and direct construction of the 2-oxazolidinone ring from an azide carbonate by reductive cyclization. Cytoxazone and its stereoisomers were stereoselec...

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Bibliographic Details
Published in:Tetrahedron letters 1999-05, Vol.40 (22), p.4203-4206
Main Authors: Sakamoto, Yasuharu, Shiraishi, Akiko, Seonhee, Jeong, Nakata, Tadashi
Format: Article
Language:English
Subjects:
Azides
Oxazolidinones
Sharpless asymmetric dihydroxylation
Stereocontrol
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Summary:Cytoxazone, a novel cytokine modulator, and its stereoisomers were stereoselectively synthesized via stereocontrolled introduction of an azide group and direct construction of the 2-oxazolidinone ring from an azide carbonate by reductive cyclization. Cytoxazone and its stereoisomers were stereoselectively synthesized via stereocontrolled introduction of an azide group and direct construction of the 2-oxazolidinone ring from an azide carbonate by reductive cyclization.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(99)00712-1