Synthesis of diuridine 3′,5′-boranophosphate: H-phosphonate approach

Diuriine 3′,5′-boranophosphate, the RNA analogue of boranophosphate nucleic acids, was synthesized by a new approach via the H-phosphonate. Two diastereomers of diuridine 3′,5′-boranophosphate were separated by reverse phase HPLC. Diuridine 3′,5′-boranophosphate was synthesized by a new H-phosphonat...

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Bibliographic Details
Published in:Tetrahedron letters 1999-06, Vol.40 (25), p.4601-4604
Main Authors: He, Kaizhang, Sergueev, Dmitri S., Sergueeva, Zinaida A., Shaw, Barbara Ramsay
Format: Article
Language:English
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Summary:Diuriine 3′,5′-boranophosphate, the RNA analogue of boranophosphate nucleic acids, was synthesized by a new approach via the H-phosphonate. Two diastereomers of diuridine 3′,5′-boranophosphate were separated by reverse phase HPLC. Diuridine 3′,5′-boranophosphate was synthesized by a new H-phosphonate approach through silylation of diuridine 3′,5′-H-phosphonate followed by boronation.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(99)00742-X