Turbotoxins A and B, novel diiodotyramine derivatives from the Japanese gastropod Turbo marmorata

Bioassay-guided separation of the aqueous ethanol extract of the viscera of the Japanese gastropod Turbo marmorata resulted in the isolation of two toxins, turbotoxins A and B. The structures were determined by spectral analysis and confirmed by organic synthesis to be diiodotyramine derivatives. Tu...

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Bibliographic Details
Published in:Tetrahedron letters 1999-07, Vol.40 (31), p.5745-5748
Main Authors: Kigoshi, Hideo, Kanematsu, Kengo, Uemura, Daisuke
Format: Article
Language:English
Subjects:
ammonium salts
biologically active compounds
marine metabolites
toxins
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Summary:Bioassay-guided separation of the aqueous ethanol extract of the viscera of the Japanese gastropod Turbo marmorata resulted in the isolation of two toxins, turbotoxins A and B. The structures were determined by spectral analysis and confirmed by organic synthesis to be diiodotyramine derivatives. Turbotoxins A and B exhibited acute toxicity against ddY mice, with LD 99 values of 1.0 and 4.0 mg/kg, respectively. Bioassay-guided separation of the aqueous ethanol extract of the viscera of the Japanese gastropod Turbo marmorata resulted in the isolation of two toxins, turbotoxins A and B. Turbotoxins A and B exhibited acute toxicity against ddY mice, with LD 99 values of 1.0 and 4.0 mg/kg, respectively.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(99)01099-0