A versatile new synthesis of 4-aryl- and heteroaryl-[3,4- c]pyrrolocarbazoles by [4+2] cycloaddition followed by palladium catalysed cross coupling

4-Bromo- and 4-trifluorosulfonyloxypyrrolo[3,4- c]carbazoles were prepared in five steps via a [4+2] cyclo-addition and were used as key intermediates in palladium-catalysed cross coupling reactions allowing the rapid generation of structurally diverse protein kinase C inhibitors. Graphic

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Bibliographic Details
Published in:Tetrahedron letters 1999-08, Vol.40 (34), p.6211-6215
Main Authors: McCort, Gary, Duclos, Olivier, Cadilhac, Caroline, Guilpain, Eric
Format: Article
Language:English
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Summary:4-Bromo- and 4-trifluorosulfonyloxypyrrolo[3,4- c]carbazoles were prepared in five steps via a [4+2] cyclo-addition and were used as key intermediates in palladium-catalysed cross coupling reactions allowing the rapid generation of structurally diverse protein kinase C inhibitors. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(99)01142-9