Transition metal complexes in organic synthesis, part 54. Improved total syntheses of the antibiotic alkaloids carbazomycin A and B

Considerably improved total syntheses of the carbazole antibiotics carbazomycin A and B are reported using a convergent iron-mediated one-pot construction of the carbazole framework by oxidative cyclization in the air. Starting from the corresponding arylamines 1 the iron-mediated oxidative cyclizat...

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Bibliographic Details
Published in:Tetrahedron letters 1999-09, Vol.40 (38), p.6915-6918
Main Authors: Knölker, Hans-Joachim, Fröhner, Wolfgang
Format: Article
Language:English
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Summary:Considerably improved total syntheses of the carbazole antibiotics carbazomycin A and B are reported using a convergent iron-mediated one-pot construction of the carbazole framework by oxidative cyclization in the air. Starting from the corresponding arylamines 1 the iron-mediated oxidative cyclization in the air was applied to highly convergent syntheses of carbazomycin A (3 steps, 65% overall yield) and B (4 steps, 55% overall yield).
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(99)01418-5