Human papillomavirus infection in esophageal carcinomas: A study of 121 lesions using multiple broad-spectrum polymerase chain reactions and literature review

To elucidate the putative role of human papillomavirus (HPV) infection in the etiology of esophageal cancer, 121 formalin-fixed, paraffin-embedded specimens originating from a non—high-incidence area for this carcinoma, from Slovenia, were screened for HPV infection using eight different polymerase...

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Bibliographic Details
Published in:Human pathology 1998-03, Vol.29 (3), p.266-271
Main Authors: Poljak, Mario, Cerar, Anton, Seme, Katja
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Carcinoma, Adenosquamous - pathology
Carcinoma, Adenosquamous - virology
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - virology
DNA, Neoplasm - genetics
DNA, Viral - analysis
Esophageal Neoplasms - pathology
Esophageal Neoplasms - virology
Esophagus
Female
Gastroenterology. Liver. Pancreas. Abdomen
HPV
human papillomaviruses
Humans
Male
Medical sciences
Middle Aged
Papillomaviridae - genetics
Papillomaviridae - isolation & purification
Papillomavirus Infections - pathology
Papillomavirus Infections - virology
PCR
polymerase chain reaction
Polymerase Chain Reaction - methods
Retrospective Studies
Slovenia
squamous cell carcinoma
Tumor Virus Infections - pathology
Tumor Virus Infections - virology
Tumors
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Summary:To elucidate the putative role of human papillomavirus (HPV) infection in the etiology of esophageal cancer, 121 formalin-fixed, paraffin-embedded specimens originating from a non—high-incidence area for this carcinoma, from Slovenia, were screened for HPV infection using eight different polymerase chain reactions (PCR). Three different HPV consensus primer sets and four primer sets specific for HPV types 6, 16, and 18 failed to detect HPV DNA sequences in any of the tumor samples. Fragments of human beta-globin gene that served as internal controls were successfully amplified from 120 of 121 specimens. Our study confirms the opinion that most esophageal cancers originating from non—high-incidence geographic areas of this cancer are not associated with HPV infection. According to the studies reviewed, it is likely that HPV infection plays a much more significant role in esophageal carcinogenesis in those areas of the world with a high incidence of ESCC.
ISSN:0046-8177
1532-8392
DOI:10.1016/S0046-8177(98)90046-6