Terazosin, doxazosin, and prazosin: current clinical experience

Lower urinary tract symptoms (LUTS) suggestive of benign prostatic obstruction are common in aging men. Nearly 25% of men >40 years of age have LUTS. Medical therapy with α-blockade is the most common method of medical therapy for benign prostatic obstruction. Multiple methods of minimally invasi...

Full description

Saved in:
Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2001-12, Vol.58 (6), p.49-54
Main Authors: Akduman, Bulent, Crawford, E.David
Format: Article
Language:English
Subjects:
Adrenergic alpha-Antagonists - adverse effects
Adrenergic alpha-Antagonists - pharmacokinetics
Adrenergic alpha-Antagonists - therapeutic use
Adult
Aged
Biological and medical sciences
Doxazosin - adverse effects
Doxazosin - pharmacokinetics
Doxazosin - therapeutic use
Genital system. Reproduction
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Prazosin - adverse effects
Prazosin - analogs & derivatives
Prazosin - pharmacokinetics
Prazosin - therapeutic use
Prostatic Hyperplasia - complications
Prostatic Hyperplasia - drug therapy
Randomized Controlled Trials as Topic
Receptors, Adrenergic, alpha - classification
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lower urinary tract symptoms (LUTS) suggestive of benign prostatic obstruction are common in aging men. Nearly 25% of men >40 years of age have LUTS. Medical therapy with α-blockade is the most common method of medical therapy for benign prostatic obstruction. Multiple methods of minimally invasive surgical therapies have been introduced in the last decade. These methods include balloon dilatation, temporary and permanent urethral stents, various laser techniques, microwave thermotherapy, transurethral needle ablation, electrovaporization, and high-intensity focused ultrasound. α-Receptor blockers to reduce the sympathetic tone of the prostate are considered as first-line therapy to relieve the symptoms of benign prostatic hyperplasia. Selective α 1-receptor blockers relax prostatic smooth muscle, relieve bladder outlet obstruction, and enhance urine flow with fewer side effects. In addition, it was determined that treating patients with α-blockers increases prostatic apoptosis. Pharmacokinetic activity, mode of action, clinical efficacy, and side effects of the selective α 1-receptor blockers terazosin, doxazosin, and prazosin are reviewed.
ISSN:0090-4295
1527-9995
DOI:10.1016/S0090-4295(01)01302-4