Correlation of Ki-67 and gelsolin expression to clinical outcome in renal clear cell carcinoma

To analyze the expression levels of Ki-67 and gelsolin in renal cell carcinoma (RCC) and determine their prognostic value in association with other clinicopathologic factors using tissue microarray technology. Histologic nuclear grade, performance status, and clinical stage are important prognostic...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2003-04, Vol.61 (4), p.845-850
Main Authors: Visapää, Harri, Bui, Matthew, Huang, Yunda, Seligson, David, Tsai, Henry, Pantuck, Allan, Figlin, Robert, Rao, Jian Y.u, Belldegrun, Arie, Horvath, Steve, Palotie, Aarno
Format: Article
Language:English
Subjects:
Adenocarcinoma, Clear Cell - immunology
Adenocarcinoma, Clear Cell - metabolism
Adenocarcinoma, Clear Cell - pathology
Adult
Aged
Biological and medical sciences
Biomarkers, Tumor - analysis
Carcinoma, Renal Cell - immunology
Carcinoma, Renal Cell - metabolism
Carcinoma, Renal Cell - pathology
Female
Gelsolin - analysis
Gelsolin - immunology
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Ki-67 Antigen - analysis
Ki-67 Antigen - immunology
Kidney - pathology
Kidney Neoplasms - immunology
Kidney Neoplasms - metabolism
Kidney Neoplasms - pathology
Kidneys
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Oligonucleotide Array Sequence Analysis
Prognosis
Survival Analysis
Tumors of the urinary system
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Description
Summary:To analyze the expression levels of Ki-67 and gelsolin in renal cell carcinoma (RCC) and determine their prognostic value in association with other clinicopathologic factors using tissue microarray technology. Histologic nuclear grade, performance status, and clinical stage are important prognostic factors in RCC. Because patients with tumors of similar grade, performance status, and stage may show a wide variation in biologic behavior and clinical outcome, additional biomarkers for RCC are needed to provide further prognostic information and possibly offer insight into the mechanisms of the disease. Using a renal cancer tissue microarray, we correlated the expression of Ki-67, a marker of cell proliferation, and gelsolin, an actin-binding protein, with grade, stage, and survival in patients with clear cell RCC. In Cox multivariate regression analysis, stage (pT) was the most significant predictor of cancer-specific survival ( P
ISSN:0090-4295
1527-9995
DOI:10.1016/S0090-4295(02)02404-4