Anticonvulsant properties of N-salicyloyltryptamine in mice

A new tryptamine analogue, N-salicyloyltryptamine (STP), a potential central nervous system (CNS) depressant, was tested in the pentylenetetrazol (PTZ) and maximal electroshock (MES) models of epilepsy in mice. When administered concurrently, STP (100 mg/kg ip) significantly reduced the number of an...

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Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2001-02, Vol.68 (2), p.199-202
Main Authors: Oliveira, Francisco A, de Almeida, Reinaldo N, Sousa, Maria de Fátima V, Barbosa-Filho, José M, Diniz, Silmara A, de Medeiros, Isac A
Format: Article
Language:English
Subjects:
Animals
Anticonvulsant activity
Anticonvulsants - chemistry
Anticonvulsants - therapeutic use
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Convulsants
Drug Evaluation, Preclinical
Electroshock
Epilepsy
Male
Maximal electroshock
Medical sciences
Mice
N-Salicyloyltryptamine
Neuropharmacology
Pentylenetetrazol
Pentylenetetrazole
Pharmacology. Drug treatments
Seizures - chemically induced
Seizures - drug therapy
Tryptamines - chemistry
Tryptamines - therapeutic use
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Summary:A new tryptamine analogue, N-salicyloyltryptamine (STP), a potential central nervous system (CNS) depressant, was tested in the pentylenetetrazol (PTZ) and maximal electroshock (MES) models of epilepsy in mice. When administered concurrently, STP (100 mg/kg ip) significantly reduced the number of animals that exhibited PTZ-induced seizures and eliminated the extensor reflex of maximal electric-induced seizures test in 50% of the experimental animals. In addition, it showed protection in the PTZ test by diminishing the death rate.
ISSN:0091-3057
1873-5177
DOI:10.1016/S0091-3057(00)00484-6