Fluticasone propionate aqueous nasal spray compared with terfenadine tablets in the treatment of seasonal allergic rhinitis

Background: Comparative studies with topical corticosteroids and antithistamines for treatment of allergic rhinitis have not always demonstrated clear distinctions between the two on the basis of therapeutic efficacy. Objective: This study was designed to compare the efficacy and tolerability of flu...

Full description

Saved in:
Bibliographic Details
Published in:Journal of allergy and clinical immunology 1996-04, Vol.97 (4), p.915-921
Main Authors: Bronsky, Edwin A., Dockhorn, Robert J., Meltzer, Eli O., Shapiro, Gail, Boltansky, Howard, LaForce, Craig, Ransom, James, Weiler, John M., Blumenthal, Malcolm, Weakley, Suzanne, Wisniewski, Michael, Field, Elizabeth, Rogenes, Paula
Format: Article
Language:English
Subjects:
Administration, Intranasal
Administration, Oral
Adolescent
Adult
Aged
Androstadienes - administration & dosage
Androstadienes - adverse effects
Androstadienes - therapeutic use
Anti-Allergic Agents - administration & dosage
Anti-Allergic Agents - adverse effects
Anti-Allergic Agents - therapeutic use
antihistamine
Biological and medical sciences
Child
comparative study
Double-Blind Method
Female
Fluticasone
Fluticasone propionate
glucocorticosteroid
Histamine and antagonists. Allergy
Humans
Male
Medical sciences
Middle Aged
Nebulizers and Vaporizers
Pharmacology. Drug treatments
Rhinitis, Allergic, Seasonal - complications
Rhinitis, Allergic, Seasonal - drug therapy
seasonal allergic rhinitis
Tablets
terfenadine
Terfenadine - administration & dosage
Terfenadine - therapeutic use
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Comparative studies with topical corticosteroids and antithistamines for treatment of allergic rhinitis have not always demonstrated clear distinctions between the two on the basis of therapeutic efficacy. Objective: This study was designed to compare the efficacy and tolerability of fluticasone propionate aqueous nasal spray with those of terfenadine in the treatment of seasonal allergic rhinitis. Methods: Three hundred forty-eight patients with allergic rhinitis were given fluicasone propionate aqueous nasal spray (200 μg once daily), terfenadine tablets (60 mg twice daily), or placebo for 4 weeks in a multicenter, randomized, double-blind, double-dummy, parallel-group study. Results: Clinician-rated total nasal symptom scores after 1, 2, 3, and 4 weeks of therapy and patient-rated total nasal symptom scores throughout treatment were significantly ( p
ISSN:0091-6749
1097-6825
DOI:10.1016/S0091-6749(96)80065-0