Abrogation of post-myeloablative chemotherapy neutropenia by ex-vivo expanded autologous CD34-positive cells

We show that absolute and severe neutropenia after high-dose therapy with melphalan with or without total body irradiation can be abrogated by cells generated ex vivo. This may change the clinical practice of haematopoietic cell transplantation and high-dose chemotherapy because the morbidity and ho...

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Bibliographic Details
Published in:The Lancet (British edition) 1999-09, Vol.354 (9184), p.1092-1093
Main Authors: Reiffers, Josy, Cailliot, Christian, Dazey, Bernard, Attal, Michel, Caraux, Jean, Boiron, Jean-Michel
Format: Article
Language:English
Subjects:
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antigens, CD34 - administration & dosage
Antigens, CD34 - blood
Antigens, CD34 - isolation & purification
Antineoplastic Agents, Alkylating - adverse effects
Biological and medical sciences
Cells, Cultured
Combined Modality Therapy
Drug toxicity and drugs side effects treatment
Emergency and intensive respiratory care
Granulocyte-Macrophage Colony-Stimulating Factor - immunology
Hematopoietic Stem Cell Transplantation - methods
Humans
Intensive care medicine
Medical sciences
Melphalan - adverse effects
Multiple Myeloma - drug therapy
Multiple Myeloma - radiotherapy
Neutropenia - chemically induced
Neutropenia - therapy
Pharmacology. Drug treatments
Toxicity: blood
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Summary:We show that absolute and severe neutropenia after high-dose therapy with melphalan with or without total body irradiation can be abrogated by cells generated ex vivo. This may change the clinical practice of haematopoietic cell transplantation and high-dose chemotherapy because the morbidity and hospitalisation associated with neutropenia could be avoided or reduced.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(99)03113-X