Novel azobenzene derivatives containing a glucopyranoside moiety. Part I: synthesis, characterisation and mutagenic properties

The synthesis of dimethylaminoazobenzene derivatives containing a β- d-glucopyranosyl ring is described. Structures have been defined by 1H NMR techniques, selective decoupling and 1H– 1H COSY. Differential thermal analysis (DTA) and thermogravimetry (TG) have been used to describe their thermal beh...

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Bibliographic Details
Published in:Dyes and pigments 2000-07, Vol.46 (1), p.29-36
Main Authors: Barni, Ermanno, Barolo, Claudia, Quagliotto, Pierluigi, Valldeperas, Josè, Viscardi, Guido
Format: Article
Language:English
Subjects:
1H NMR analysis
Ames test
Azobenzene derivatives
Biological and medical sciences
Chemical mutagenesis
Dyes
Glucopyranosides
Medical sciences
Mutagenicity
Thermal analysis
Toxicology
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Summary:The synthesis of dimethylaminoazobenzene derivatives containing a β- d-glucopyranosyl ring is described. Structures have been defined by 1H NMR techniques, selective decoupling and 1H– 1H COSY. Differential thermal analysis (DTA) and thermogravimetry (TG) have been used to describe their thermal behaviour. Genotoxicity (Ames test) comparisons with their p-methoxy counterparts have shown the effect of β- d-glucopyranosyl on reducing the mutagenicity.
ISSN:0143-7208
1873-3743
DOI:10.1016/S0143-7208(00)00033-4