Synthesis of 3H-1,8,9-trimethylthieno[3′,2′:6,7]naphtho [2,1-b]pyran-3-one with potential photobiological activity

3H-1,8,9-Trimethylthieno[3′,2′:6,7]naphtho[2,1-b]pyran-3-one, a potential photobiological agent, was synthesized in six steps starting from commercially available 2,7-naphthalenediol. The key step involved is a Newman–Kwart rearrangement of naphthopyrone 2. The structures of 6 and its precursors wer...

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Bibliographic Details
Published in:Dyes and pigments 1998-04, Vol.37 (2), p.113-119
Main Authors: Tao, Zhi-Fu, Qian, Xuhong, Zhang, Yinbi, Fan, Mingcai
Format: Article
Language:English
Subjects:
3H-1,8,9-trimethylthieno[3′,2′:6,7]naphtho[2,1-b]pyran-3-one
Biological and medical sciences
furonaphthopyrones
Medical sciences
photobiological agent
Photoradiation therapy and photosensitizing agent
Treatment with physical agents
Treatment. General aspects
Tumors
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Summary:3H-1,8,9-Trimethylthieno[3′,2′:6,7]naphtho[2,1-b]pyran-3-one, a potential photobiological agent, was synthesized in six steps starting from commercially available 2,7-naphthalenediol. The key step involved is a Newman–Kwart rearrangement of naphthopyrone 2. The structures of 6 and its precursors were fully characterized and their absorption and fluorescence spectra recorded.
ISSN:0143-7208
1873-3743
DOI:10.1016/S0143-7208(97)00043-0