Effectiveness of ranitidine 150 mg at bedtime as maintenance therapy for healed gastric ulcers

As many as 89% of gastric ulcer patients experience ulcer recurrences within 1 year of successful healing with conventional antiulcer therapies. Because ranitidine is effective in the healing of gastric and duodenal ulcers and the maintenance of healed duodenal ulcers, we hypothesized that ranitidin...

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Bibliographic Details
Published in:Clinical therapeutics 1996-11, Vol.18 (6), p.1175-1183
Main Authors: Sue, Samuel O., McCarty Dawson, Debra, Johnson Brown, Jeanine A., Wood, David R., Kleoudis, Christi S.
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Adult
Aged
Anti-Ulcer Agents - adverse effects
Anti-Ulcer Agents - therapeutic use
Bed Rest
Biological and medical sciences
Digestive system
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Female
Follow-Up Studies
Gastroscopy
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Ranitidine - adverse effects
Ranitidine - therapeutic use
Recurrence
Regression Analysis
Safety
Stomach Ulcer - pathology
Stomach Ulcer - prevention & control
Treatment Outcome
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Summary:As many as 89% of gastric ulcer patients experience ulcer recurrences within 1 year of successful healing with conventional antiulcer therapies. Because ranitidine is effective in the healing of gastric and duodenal ulcers and the maintenance of healed duodenal ulcers, we hypothesized that ranitidine would also be effective in the maintenance of healed gastric ulcers. A 48-week, placebo-controlled, randomized, double-blind, multicenter trial was conducted to compare ranitidine 150 mg administered at bedtime with placebo for the maintenance of healed gastric ulcers. Endoscopies were performed at baseline and repeated after 12, 24, 36, and 48 weeks of treatment. Gastric ulcer recurrence rates at each scheduled endoscopy were significantly lower in patients receiving ranitidine (5%, 13%, 16%, and 19%, respectively) compared with those receiving placebo (20%, 30%, 40%, and 50%, respectively). Compared with placebo, ranitidine was more effective in maintaining healed gastric ulcers regardless of previous gastric ulcer history, smoking status, age (
ISSN:0149-2918
1879-114X
DOI:10.1016/S0149-2918(96)80072-5